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The nuclear receptor PPARγ individually responds to serotonin- and fatty acid-metabolites
The nuclear receptor, peroxisome proliferator-activated receptor γ (PPARγ), recognizes various synthetic and endogenous ligands by the ligand-binding domain. Fatty-acid metabolites reportedly activate PPARγ through conformational changes of the Ω loop. Here, we report that serotonin metabolites act...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2957204/ https://ncbi.nlm.nih.gov/pubmed/20717101 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.197 |
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