HIV Tat Elicits Microglial Glutamate Release: Role of NAPDH Oxidase and the Cystine-Glutamate Antiporter

Excitotoxicity and/or microglial reactivity might underlie neurologic dysfunction in HIV patients. The HIV regulatory protein Tat is both neurotoxic and pro-inflammatory, suggesting that Tat might participate in the pathogenesis of HIV-associated neurocognitive disorders (HAND). The present study wa...

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Autores principales: Gupta, Sunita, Knight, Alecia G., Gupta, Shruti, Knapp, Pamela E., Hauser, Kurt F., Keller, Jeffrey N., Bruce-Keller, Annadora J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2956797/
https://ncbi.nlm.nih.gov/pubmed/20849923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2010.09.019
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