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Serpin-1 splicing isoform J inhibits the proSpätzle-activating proteinase HP8 to regulate expression of antimicrobial hemolymph proteins in Manduca sexta

The innate immune system of insects include the Toll pathway, which is mediated by an extracellular serine proteinase cascade. In the tobacco hornworm, Manduca sexta, hemolymph proteinase 8 (HP8) promotes the synthesis of antimicrobial proteins by cleaving proSpätzle, the putative ligand of M. sexta...

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Detalhes bibliográficos
Main Authors: An, Chunju, Ragan, Emily J., Kanost, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2956776/
https://ncbi.nlm.nih.gov/pubmed/20851714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dci.2010.09.004
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