Reversible Block of Mouse Neural Stem Cell Differentiation in the Absence of Dicer and MicroRNAs

BACKGROUND: To investigate the functions of Dicer and microRNAs in neural stem (NS) cell self-renewal and neurogenesis, we established neural stem cell lines from the embryonic mouse Dicer-null cerebral cortex, producing neural stem cell lines that lacked all microRNAs. PRINCIPAL FINDINGS: Dicer-nul...

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Detalhes bibliográficos
Main Authors: Andersson, Therese, Rahman, Sabhi, Sansom, Stephen N., Alsiö, Jessica M., Kaneda, Masahiro, Smith, James, O'Carroll, Donal, Tarakhovsky, Alexander, Livesey, Frederick J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2956652/
https://ncbi.nlm.nih.gov/pubmed/20976144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013453
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