Deficiency in phosphorylase phosphatase activity despite elevated protein phosphatase type-1 catalytic subunit in skeletal muscle from insulin-resistant subjects.

Glycogen synthase is activated by protein phosphatase type-1 (PP-1). The spontaneous PP-1 activity accounts for only a small fraction of total PP-1 activity, which can be exposed by trypsin digestion of inhibitor proteins in the presence of Mn2+. We determined total PP-1 activity in muscle biopsies...

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Pubblicato in:	J Clin Invest
Autori principali:	Nyomba, B L, Brautigan, D L, Schlender, K K, Wang, W, Bogardus, C, Mott, D M
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1991
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC295665/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1658044/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115464
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