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Deficiency in phosphorylase phosphatase activity despite elevated protein phosphatase type-1 catalytic subunit in skeletal muscle from insulin-resistant subjects.

Glycogen synthase is activated by protein phosphatase type-1 (PP-1). The spontaneous PP-1 activity accounts for only a small fraction of total PP-1 activity, which can be exposed by trypsin digestion of inhibitor proteins in the presence of Mn2+. We determined total PP-1 activity in muscle biopsies...

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Udgivet i:J Clin Invest
Principais autores: Nyomba, B L, Brautigan, D L, Schlender, K K, Wang, W, Bogardus, C, Mott, D M
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 1991
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC295665/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1658044/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115464
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