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Context-Dependent Cell Cycle Checkpoint Abrogation by a Novel Kinase Inhibitor
BACKGROUND: Checkpoint kinase 1 and 2 (Chk1/Chk2), and the Aurora kinases play a critical role in the activation of the DNA damage response and mitotic spindle checkpoints. We have identified a novel inhibitor of these kinases and utilized this molecule to probe the functional interplay between thes...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Public Library of Science
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2956624/ https://ncbi.nlm.nih.gov/pubmed/20976184 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013123 |
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