Novel tricyclic pyrazole BRAF inhibitors with imidazole or furan central scaffolds

V-RAF murine sarcoma viral oncogene homolog B1 (BRAF) is a serine/threonine-specific protein kinase that is mutated with high frequency in cutaneous melanoma, and many other cancers. Inhibition of mutant BRAF is an attractive therapeutic approach for the treatment of melanoma. A triarylimidazole BRA...

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Autors principals: Niculescu-Duvaz, Dan, Niculescu-Duvaz, Ion, Suijkerbuijk, Bart M.J.M., Ménard, Delphine, Zambon, Alfonso, Nourry, Arnaud, Davies, Lawrence, Manne, Helen A., Friedlos, Frank, Ogilvie, Lesley, Hedley, Douglas, Takle, Andrew K., Wilson, David M., Pons, Jean-Francois, Coulter, Tom, Kirk, Ruth, Cantarino, Neus, Whittaker, Steven, Marais, Richard, Springer, Caroline J.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier Science 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2956513/
https://ncbi.nlm.nih.gov/pubmed/20667740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.06.031
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