Indoleamine 2,3-dioxygenase and 3-hydroxykynurenine modifications are found in the neuropathology of Alzheimer's disease

Tryptophan metabolism, through the kynurenine pathway, produces neurotoxic intermediates that are implicated in the pathogenesis of Alzheimer's disease. In particular, oxidative stress via 3-hydroxykynurenine (3-HK) and its cleaved product 3-hydroxyanthranilic acid (3-HAA) significantly damages...

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Detalhes bibliográficos
Main Authors: Bonda, David J., Mailankot, Maneesh, Stone, Jeremy G., Garrett, Matthew R., Staniszewska, Magdalena, Castellani, Rudy J., Siedlak, Sandra L., Zhu, Xiongwei, Lee, Hyoung-gon, Perry, George, Nagaraj, Ram H., Smith, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2956440/
https://ncbi.nlm.nih.gov/pubmed/20663292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1179/174329210X12650506623645
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