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Synergistic induction of MAP kinase phosphatase-1 by thrombin and epidermal growth factor requires vascular endothelial growth factor receptor-2
OBJECTIVE: We have previously reported that MAP kinase phosphatase-1 (MKP-1) is induced by thrombin and VEGF. We recently observed that EGF synergizes with thrombin to super induce MKP-1. The objective of the study was to determine the molecular mechanism underlying this synergistic response. METHOD...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2956164/ https://ncbi.nlm.nih.gov/pubmed/20671228 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.110.212399 |
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