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Synergistic induction of MAP kinase phosphatase-1 by thrombin and epidermal growth factor requires vascular endothelial growth factor receptor-2

OBJECTIVE: We have previously reported that MAP kinase phosphatase-1 (MKP-1) is induced by thrombin and VEGF. We recently observed that EGF synergizes with thrombin to super induce MKP-1. The objective of the study was to determine the molecular mechanism underlying this synergistic response. METHOD...

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Bibliografski detalji
Glavni autori: Chandrasekharan, Unni M, Waitkus, Matthew, Kinney, Corttrell, Walters-Stewart, Alicia, DiCorleto, Paul E.
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2956164/
https://ncbi.nlm.nih.gov/pubmed/20671228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.110.212399
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