Disulfiram Attenuates Drug-Primed Reinstatement of Cocaine Seeking via Inhibition of Dopamine β-Hydroxylase

The antialcoholism medication disulfiram (Antabuse) inhibits aldehyde dehydrogenase (ALDH), which results in the accumulation of acetaldehyde upon ethanol ingestion and produces the aversive ‘Antabuse reaction' that deters alcohol consumption. Disulfiram has also been shown to deter cocaine use...

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Main Authors: Schroeder, Jason P, Cooper, Debra A, Schank, Jesse R, Lyle, Megan A, Gaval-Cruz, Meriem, Ogbonmwan, Yvonne E, Pozdeyev, Nikita, Freeman, Kimberly G, Iuvone, P Michael, Edwards, Gaylen L, Holmes, Philip V, Weinshenker, David
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2010
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2956132/
https://ncbi.nlm.nih.gov/pubmed/20736996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2010.127
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