Evaluation of Approaches to Identify Associated SNPs That Explain the Linkage Evidence in Nuclear Families with Affected Siblings

Linkage analysis is often followed by association mapping to localize disease variants. In this paper, we evaluate approaches to determine how much of the observed linkage evidence, namely the identity-by-descent (IBD) sharing at the linkage peak, is explained by associated SNPs. We study several me...

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Bibliographic Details
Main Authors: Chen, Ming-Huei, Van Eerdewegh, Paul, Vincent, Quentin B., Alcais, Alexandre, Abel, Laurent, Dupuis, Josée
Format: Artigo
Language:Inglês
Published: S. Karger AG 2010
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Original Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2956012/
https://ncbi.nlm.nih.gov/pubmed/19996608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000264448
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