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Evaluation of Approaches to Identify Associated SNPs That Explain the Linkage Evidence in Nuclear Families with Affected Siblings

Linkage analysis is often followed by association mapping to localize disease variants. In this paper, we evaluate approaches to determine how much of the observed linkage evidence, namely the identity-by-descent (IBD) sharing at the linkage peak, is explained by associated SNPs. We study several me...

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Detalhes bibliográficos
Main Authors: Chen, Ming-Huei, Van Eerdewegh, Paul, Vincent, Quentin B., Alcais, Alexandre, Abel, Laurent, Dupuis, Josée
Formato: Artigo
Idioma:Inglês
Publicado em: S. Karger AG 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2956012/
https://ncbi.nlm.nih.gov/pubmed/19996608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000264448
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