Does gene deletion of AMPA GluA1 phenocopy features of schizoaffective disorder?

Glutamatergic dysfunction is strongly implicated in schizophrenia and mood disorders. GluA1 knockout (KO) mice display schizophrenia- and depression-related abnormalities. Here, we asked whether GluA1 KO show mania-related abnormalities. KO were tested for behavior in approach/avoid conflict tests,...

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Main Authors: Fitzgerald, Paul J., Barkus, Chris, Feyder, Michael, Wiedholz, Lisa M., Chen, Yi-Chyan, Karlsson, Rose-Marie, Machado-Vieira, Rodrigo, Graybeal, Carolyn, Sharp, Trevor, Zarate, Carlos, Harvey-White, Judith, Du, Jing, Sprengel, Rolf, Gass, Peter, Bannerman, David, Holmes, Andrew
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2955784/
https://ncbi.nlm.nih.gov/pubmed/20699120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2010.08.005
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