Do GluA1 knockout mice exhibit behavioral abnormalities relevant to the negative or cognitive symptoms of schizophrenia and schizoaffective disorder?

The glutamate system has been strongly implicated in the pathophysiology of psychotic illnesses, including schizophrenia and schizoaffective disorder. We recently found that knockout (KO) mice lacking the AMPA GluA1 subunit displayed behavioral abnormalities relevant to some of the positive symptoms...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Barkus, Chris, Feyder, Michael, Graybeal, Carolyn, Wright, Tara, Wiedholz, Lisa, Izquierdo, Alicia, Kiselycznyk, Carly, Schmitt, Wolfram, Sanderson, David J., Rawlins, J. Nicholas P., Saksida, Lisa M., Bussey, Timothy J., Sprengel, Rolf, Bannerman, David, Holmes, Andrew
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2011
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3208051/
https://ncbi.nlm.nih.gov/pubmed/21693126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2011.06.005
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