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Survivin enhances motility of melanoma cells by supporting Akt activation and α5 integrin upregulation

Survivin expression in melanoma is inversely correlated with patient survival. Transgenic mice harboring melanocyte-specific overexpression of survivin exhibit increased susceptibility to UV-induced melanoma and metastatic progression. To understand the mechanistic basis for metastatic progression,...

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Библиографические подробности
Главные авторы: McKenzie, Jodi A., Liu, Tong, Goodson, Agnessa Gadeliya, Grossman, Douglas
Формат: Artigo
Язык:Inglês
Опубликовано: 2010
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2955769/
https://ncbi.nlm.nih.gov/pubmed/20807805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-0194
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