Ligand bridging mediates integrin alpha IIb beta 3 (platelet GPIIB-IIIA) dependent homotypic and heterotypic cell-cell interactions.

The aggregation of cells bearing recombinant integrin alpha IIb beta 3 (platelet GPIIb-IIIa) has been analyzed by two-color flow cytometry. As in normal platelets, aggregation requires functional alpha IIb beta 3, "activation" of alpha IIb beta 3, and fibrinogen (fg) binding to alpha IIb beta 3. Cel...

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Pubblicato in:	J Clin Invest
Autori principali:	Gawaz, M P, Loftus, J C, Bajt, M L, Frojmovic, M M, Plow, E F, Ginsberg, M H
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1991
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC295567/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1918367/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115412
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