Treatment with the C5a receptor antagonist ADC-1004 reduces myocardial infarction in a porcine ischemia-reperfusion model

BACKGROUND: Polymorphonuclear neutrophils, stimulated by the activated complement factor C5a, have been implicated in cardiac ischemia/reperfusion injury. ADC-1004 is a competitive C5a receptor antagonist that has been shown to inhibit complement related neutrophil activation. ADC-1004 shields the n...

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Autori principali: van der Pals, Jesper, Koul, Sasha, Andersson, Patrik, Götberg, Matthias, Ubachs, Joey FA, Kanski, Mikael, Arheden, Håkan, Olivecrona, Göran K, Larsson, Bengt, Erlinge, David
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2010
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2955599/
https://ncbi.nlm.nih.gov/pubmed/20875134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2261-10-45
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