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Bioreducible Liposomes for Gene Delivery: From the Formulation to the Mechanism of Action

BACKGROUND: A promising strategy to create stimuli-responsive gene delivery systems is to exploit the redox gradient between the oxidizing extracellular milieu and the reducing cytoplasm in order to disassemble DNA/cationic lipid complexes (lipoplexes). On these premises, we previously described the...

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Detalhes bibliográficos
Main Authors: Candiani, Gabriele, Pezzoli, Daniele, Ciani, Laura, Chiesa, Roberto, Ristori, Sandra
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2955545/
https://ncbi.nlm.nih.gov/pubmed/20976172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013430
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