Fibrates downregulate apolipoprotein C-III expression independent of induction of peroxisomal acyl coenzyme A oxidase. A potential mechanism for the hypolipidemic action of fibrates.

Epidemiological and transgenic animal studies have implicated apo C-III as a major determinant of plasma triglyceride metabolism. Since fibrates are very efficient in lowering triglycerides, it was investigated whether fibrates regulate apo C-III gene expression. Different fibrates lowered rat liver...

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Bibliographic Details
Main Authors: Staels, B, Vu-Dac, N, Kosykh, V A, Saladin, R, Fruchart, J C, Dallongeville, J, Auwerx, J
Format: Artigo
Language:Inglês
Published: 1995
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC295538/
https://ncbi.nlm.nih.gov/pubmed/7860752
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