Fibrates downregulate apolipoprotein C-III expression independent of induction of peroxisomal acyl coenzyme A oxidase. A potential mechanism for the hypolipidemic action of fibrates.

Epidemiological and transgenic animal studies have implicated apo C-III as a major determinant of plasma triglyceride metabolism. Since fibrates are very efficient in lowering triglycerides, it was investigated whether fibrates regulate apo C-III gene expression. Different fibrates lowered rat liver...

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Vydáno v:	J Clin Invest
Hlavní autoři:	Staels, B, Vu-Dac, N, Kosykh, V A, Saladin, R, Fruchart, J C, Dallongeville, J, Auwerx, J
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Clinical Investigation 1995
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC295538/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7860752/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117717
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