The lethal effects of cytokine-induced nitric oxide on cardiac myocytes are blocked by nitric oxide synthase antagonism or transforming growth factor beta.

Inducible nitric oxide (NO) produced by macrophages is cytotoxic to invading organisms and has an important role in host defense. Recent studies have demonstrated inducible NO production within the heart, and that cytokine-induced NO mediates alterations in cardiac contractility, but the cytotoxic p...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Pinsky, D J, Cai, B, Yang, X, Rodriguez, C, Sciacca, R R, Cannon, P J
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1995
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC295534/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7532189/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117713
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