The lethal effects of cytokine-induced nitric oxide on cardiac myocytes are blocked by nitric oxide synthase antagonism or transforming growth factor beta.

Inducible nitric oxide (NO) produced by macrophages is cytotoxic to invading organisms and has an important role in host defense. Recent studies have demonstrated inducible NO production within the heart, and that cytokine-induced NO mediates alterations in cardiac contractility, but the cytotoxic p...

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Dades bibliogràfiques
Publicat a:J Clin Invest
Autors principals: Pinsky, D J, Cai, B, Yang, X, Rodriguez, C, Sciacca, R R, Cannon, P J
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 1995
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC295534/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7532189/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117713
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