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Proteolytic processing of protocadherin proteins requires endocytosis

The α-, β-, and γ-protocadherins (Pcdhα, Pcdhβ, and Pcdhγ) comprise a large family of single-pass transmembrane proteins predominantly expressed in the nervous system. These proteins contain six cadherin-like extracellular domains, and proteolysis of Pcdhα and Pcdhγ by the γ-secretase complex releas...

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Bibliografski detalji
Glavni autori: Buchanan, Sean M., Schalm, Stefanie S., Maniatis, Tom
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2010
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2955128/
https://ncbi.nlm.nih.gov/pubmed/20876099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1013105107
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