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Glatiramer acetate triggers PI3Kδ/Akt and MEK/ERK pathways to induce IL-1 receptor antagonist in human monocytes

Glatiramer acetate (GA), an immunomodulator used in multiple sclerosis (MS) therapy, induces the production of secreted IL-1 receptor antagonist (sIL-1Ra), a natural inhibitor of IL-1β, in human monocytes, and in turn enhances sIL-1Ra circulating levels in MS patients. GA is a mixture of peptides wi...

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Bibliografiske detaljer
Main Authors: Carpintero, Rakel, Brandt, Karim J., Gruaz, Lyssia, Molnarfi, Nicolas, Lalive, Patrice H., Burger, Danielle
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2955124/
https://ncbi.nlm.nih.gov/pubmed/20876102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1009443107
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