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Induced pluripotent stem cell models of the genomic imprinting disorders Angelman and Prader–Willi syndromes

Angelman syndrome (AS) and Prader–Willi syndrome (PWS) are neurodevelopmental disorders of genomic imprinting. AS results from loss of function of the ubiquitin protein ligase E3A (UBE3A) gene, whereas the genetic defect in PWS is unknown. Although induced pluripotent stem cells (iPSCs) provide inva...

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מידע ביבליוגרפי
Main Authors: Chamberlain, Stormy J., Chen, Pin-Fang, Ng, Khong Y., Bourgois-Rocha, Fany, Lemtiri-Chlieh, Fouad, Levine, Eric S., Lalande, Marc
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2010
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2955112/
https://ncbi.nlm.nih.gov/pubmed/20876107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1004487107
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