Signaling through CD40 rescues IgE but not IgG or IgA secretion in X-linked immunodeficiency with hyper-IgM.

The ligand for CD40 (CD40L) is a membrane protein on activated T cells that induces B cell proliferation and differentiation. Several mutations of the CD40L gene were reported responsible for defective class switching of B cells in an X-linked immunodeficiency with hyper IgM (X-HIM). We studied four...

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Bibliografiske detaljer

Udgivet i:	J Clin Invest
Principais autores:	Saiki, O, Tanaka, T, Wada, Y, Uda, H, Inoue, A, Katada, Y, Izeki, M, Iwata, M, Nunoi, H, Matsuda, I
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Clinical Investigation 1995
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC295502/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7532185/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117692
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