Signaling through CD40 rescues IgE but not IgG or IgA secretion in X-linked immunodeficiency with hyper-IgM.

The ligand for CD40 (CD40L) is a membrane protein on activated T cells that induces B cell proliferation and differentiation. Several mutations of the CD40L gene were reported responsible for defective class switching of B cells in an X-linked immunodeficiency with hyper IgM (X-HIM). We studied four...

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Autors principals: Saiki, O, Tanaka, T, Wada, Y, Uda, H, Inoue, A, Katada, Y, Izeki, M, Iwata, M, Nunoi, H, Matsuda, I
Format: Artigo
Idioma:Inglês
Publicat: 1995
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC295502/
https://ncbi.nlm.nih.gov/pubmed/7532185
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