Knockdown and overexpression of Unc-45b result in defective myofibril organization in skeletal muscles of zebrafish embryos

BACKGROUND: Unc-45 is a myosin chaperone and a Hsp90 co-chaperone that plays a key role in muscle development. Genetic and biochemical studies in C. elegans have demonstrated that Unc-45 facilitates the process of myosin folding and assembly in body wall muscles. Loss or overexpression of Unc-45 in...

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Главные авторы: Bernick, Elena P, Zhang, Pei-Jun, Du, Shaojun
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2010
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2954953/
https://ncbi.nlm.nih.gov/pubmed/20849610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2121-11-70
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