Construction of peptides encompassing multideterminant clusters of human immunodeficiency virus envelope to induce in vitro T cell responses in mice and humans of multiple MHC types.

To make synthetic peptide vaccines effective in a broad population of outbred humans, one would have to incorporate enough antigenic determinants to elicit recognition by T cells of most HLA types. We have previously defined multideterminant regions of the human immunodeficiency virus (HIV) envelope...

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Main Authors: Berzofsky, J A, Pendleton, C D, Clerici, M, Ahlers, J, Lucey, D R, Putney, S D, Shearer, G M
Formato: Artigo
Idioma:Inglês
Publicado: 1991
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC295474/
https://ncbi.nlm.nih.gov/pubmed/1715888
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