Intraarticular factor IX protein or gene replacement protects against development of hemophilic synovitis in the absence of circulating factor IX

Hemophilic bleeding into joints causes synovial and microvascular proliferation and inflammation (hemophilic synovitis) that contribute to end-stage joint degeneration (hemophilic arthropathy), the major morbidity of hemophilia. New therapies are needed for joint deterioration that progresses despit...

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Detalhes bibliográficos
Main Authors: Sun, Junjiang, Hakobyan, Narine, Valentino, Leonard A., Feldman, Brian L., Samulski, R. Jude, Monahan, Paul E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Hemostasis, Thrombosis, and Vascular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2954682/
https://ncbi.nlm.nih.gov/pubmed/18716130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-01-131417
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