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Protein Flexibility and Conformational Entropy in Ligand Design Targeting the Carbohydrate Recognition Domain of Galectin-3
[Image: see text] Rational drug design is predicated on knowledge of the three-dimensional structure of the protein−ligand complex and the thermodynamics of ligand binding. Despite the fundamental importance of both enthalpy and entropy in driving ligand binding, the role of conformational entropy i...
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| 主要な著者: | , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Chemical Society
2010
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| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2954529/ https://ncbi.nlm.nih.gov/pubmed/20873837 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja105852y |
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