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The structure of the first representative of Pfam family PF06475 reveals a new fold with possible involvement in glycolipid metabolism

The crystal structure of PA1994 from Pseudomonas aeruginosa, a member of the Pfam PF06475 family classified as a domain of unknown function (DUF1089), reveals a novel fold comprising a 15-stranded β-sheet wrapped around a single α-helix that assembles into a tight dimeric arrangement. The remote str...

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Auteurs principaux: Bakolitsa, Constantina, Kumar, Abhinav, McMullan, Daniel, Krishna, S. Sri, Miller, Mitchell D., Carlton, Dennis, Najmanovich, Rafael, Abdubek, Polat, Astakhova, Tamara, Chiu, Hsiu-Ju, Clayton, Thomas, Deller, Marc C., Duan, Lian, Elias, Ylva, Feuerhelm, Julie, Grant, Joanna C., Grzechnik, Slawomir K., Han, Gye Won, Jaroszewski, Lukasz, Jin, Kevin K., Klock, Heath E., Knuth, Mark W., Kozbial, Piotr, Marciano, David, Morse, Andrew T., Nigoghossian, Edward, Okach, Linda, Oommachen, Silvya, Paulsen, Jessica, Reyes, Ron, Rife, Christopher L., Trout, Christina V., van den Bedem, Henry, Weekes, Dana, White, Aprilfawn, Xu, Qingping, Hodgson, Keith O., Wooley, John, Elsliger, Marc-André, Deacon, Ashley M., Godzik, Adam, Lesley, Scott A., Wilson, Ian A.
Format: Artigo
Langue:Inglês
Publié: International Union of Crystallography 2009
Sujets:
New Folds
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2954207/
https://ncbi.nlm.nih.gov/pubmed/20944213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309109022684
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