DNA Damage Drives an Activin A-Dependent Induction of COX-2 in Premalignant Cells and Lesions

COX-2 catalyzes the rate-limiting step in the synthesis of prostaglandins. Its overexpression induces numerous tumor-promoting phenotypes and is associated with cancer metastasis and poor clinical outcome. Although COX-2 inhibitors are promising chemotherapeutic and chemopreventative agents for canc...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Fordyce, Colleen, Fessenden, Tim, Pickering, Curtis, Jung, Jason, Singla, Veena, Berman, Hal, Tlsty, Thea
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2009
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2954106/
https://ncbi.nlm.nih.gov/pubmed/20028875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-09-0229
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