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Phosphorylation-Dependent Regulation of PSF by GSK3 controls CD45 Alternative Splicing
Signal-induced alternative splicing of the CD45 gene in human T cells is essential for proper immune function. Skipping of the CD45 variable exons is controlled, in large part, by the recruitment of PSF to the pre-mRNA substrate upon T cell activation; however, the signaling cascade leading to exon...
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| Autors principals: | , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2954053/ https://ncbi.nlm.nih.gov/pubmed/20932480 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.09.013 |
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