A new dominant peroxiredoxin allele identified by whole-genome re-sequencing of random mutagenized yeast causes oxidant-resistance and premature aging

The combination of functional genomics with next generation sequencing facilitates new experimental strategies for addressing complex biological phenomena. Here, we report the identification of a gain-of-function allele of peroxiredoxin (thioredoxin peroxidase, Tsa1p) via whole-genome re-sequencing...

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Detalhes bibliográficos
Main Authors: Timmermann, Bernd, Jarolim, Stefanie, Rußmayer, Hannes, Kerick, Martin, Michel, Steve, Krüger, Antje, Bluemlein, Katharina, Laun, Peter, Grillari, Johannes, Lehrach, Hans, Breitenbach, Michael, Ralser, Markus
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2954039/
https://ncbi.nlm.nih.gov/pubmed/20729566
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