A Quantitative Proteomics Design for Systematic Identification of Protease Cleavage Events

We present here a novel proteomics design for systematic identification of protease cleavage events by quantitative N-terminal proteomics, circumventing the need for time-consuming manual validation. We bypass the singleton detection problem of protease-generated neo-N-terminal peptides by introduci...

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Autori principali: Impens, Francis, Colaert, Niklaas, Helsens, Kenny, Ghesquière, Bart, Timmerman, Evy, De Bock, Pieter-Jan, Chain, Benjamin M., Vandekerckhove, Joël, Gevaert, Kris
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Biochemistry and Molecular Biology 2010
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2953924/
https://ncbi.nlm.nih.gov/pubmed/20627866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M110.001271
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