The Hyperthermophilic Euryarchaeon Archaeoglobus fulgidus Repairs Uracil by Single-Nucleotide Replacement

Hydrolytic deamination of cytosine to uracil in cellular DNA is a major source of C-to-T transition mutations if uracil is not repaired by the DNA base excision repair (BER) pathway. Since deamination increases rapidly with temperature, hyperthermophiles, in particular, are expected to succumb to su...

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Main Authors: Knævelsrud, Ingeborg, Moen, Marivi N., Grøsvik, Kristin, Haugland, Gyri T., Birkeland, Nils-Kåre, Klungland, Arne, Leiros, Ingar, Bjelland, Svein
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2010
Fag:
Genetics and Molecular Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2953685/
https://ncbi.nlm.nih.gov/pubmed/20453094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00135-10
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