LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells

LIM kinases 1 and 2 (LIMK1/2) are centrally positioned regulators of actin cytoskeleton dynamics. Using siRNA-mediated knockdown or a novel small molecule inhibitor, we show LIMK is required for path generation by leading tumor cells and nontumor stromal cells during collective tumor cell invasion....

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Detalhes bibliográficos
Main Authors: Scott, Rebecca W., Hooper, Steven, Crighton, Diane, Li, Ang, König, Ireen, Munro, June, Trivier, Elisabeth, Wickman, Grant, Morin, Pierre, Croft, Daniel R., Dawson, John, Machesky, Laura, Anderson, Kurt I., Sahai, Erik A., Olson, Michael F.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2010
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2953444/
https://ncbi.nlm.nih.gov/pubmed/20876278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201002041
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