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Otoferlin is a calcium sensor that directly regulates SNARE-mediated membrane fusion
Otoferlin is a large multi–C2 domain protein proposed to act as a calcium sensor that regulates synaptic vesicle exocytosis in cochlear hair cells. Although mutations in otoferlin have been associated with deafness, its contribution to neurotransmitter release is unresolved. Using recombinant protei...
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| Hlavní autoři: | , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
The Rockefeller University Press
2010
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| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2953437/ https://ncbi.nlm.nih.gov/pubmed/20921140 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201002089 |
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