Tamoxifen blocks chloride channels. A possible mechanism for cataract formation.

Tamoxifen is an antiestrogen frequently used in the treatment of breast cancer and is currently being assessed as a prophylactic for those at high risk of developing tumors. We have found that tamoxifen and its derivatives are high-affinity blockers of specific chloride channels. This blockade appea...

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Autors principals: Zhang, J J, Jacob, T J, Valverde, M A, Hardy, S P, Mintenig, G M, Sepúlveda, F V, Gill, D R, Hyde, S C, Trezise, A E, Higgins, C F
Format: Artigo
Idioma:Inglês
Publicat: 1994
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC295332/
https://ncbi.nlm.nih.gov/pubmed/7929848
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