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Snapin-regulated late endosomal transport is critical for efficient autophagy-lysosomal function in neurons
Neuron maintenance and survival require late endocytic transport from distal processes to the soma where lysosomes are predominantly localized. Here, we report a role for Snapin in attaching dynein to late endosomes through its intermediate chain (DIC). Snapin (−/−) neurons exhibit aberrant accumula...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2953270/ https://ncbi.nlm.nih.gov/pubmed/20920792 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2010.09.022 |
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