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Axonal autophagosomes recruit dynein for retrograde transport through fusion with late endosomes

Efficient degradation of autophagic vacuoles (AVs) via lysosomes is an important cellular homeostatic process. This is particularly challenging for neurons because mature acidic lysosomes are relatively enriched in the soma. Although dynein-driven retrograde transport of AVs was suggested, a fundame...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:J Cell Biol
Hauptverfasser: Cheng, Xiu-Tang, Zhou, Bing, Lin, Mei-Yao, Cai, Qian, Sheng, Zu-Hang
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4427784/
https://ncbi.nlm.nih.gov/pubmed/25940348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201412046
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