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A Determinant of Sindbis Virus Neurovirulence Enables Efficient Disruption of Jak/STAT Signaling

Previous studies with Venezuelan equine encephalitis virus and Sindbis virus (SINV) indicate that alphaviruses are capable of suppressing the cellular response to type I and type II interferons (IFNs) by disrupting Jak/STAT signaling; however, the relevance of this signaling inhibition toward pathog...

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Autors principals: Simmons, Jason D., Wollish, Amy C., Heise, Mark T.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2953173/
https://ncbi.nlm.nih.gov/pubmed/20739538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00577-10
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