Development of a Genetic System for Combinatorial Biosynthesis of Lipopeptides in Streptomyces fradiae and Heterologous Expression of the A54145 Biosynthesis Gene Cluster

A54145 factors are calcium-dependent lipopeptide antibiotics produced by Streptomyces fradiae NRRL 18160. A54145 is structurally related to the clinically important daptomycin, and as such may be a useful scaffold for the development of a novel lipopeptide antibiotic. We developed methods to genetic...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Alexander, Dylan C., Rock, Jessica, He, Xiaowei, Brian, Paul, Miao, Vivian, Baltz, Richard H.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2010
Fag:
Genetics and Molecular Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2953024/
https://ncbi.nlm.nih.gov/pubmed/20802082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.01248-10
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker