Modulation of the Ribonucleotide Reductase-Antimetabolite Drug Interaction in Cancer Cell Lines

RRM1 is a determinant of gemcitabine efficacy in cancer patients. However, the precision of predicting tumor response based on RRM1 levels is not optimal. We used gene-specific overexpression and RNA interference to assess RRM1's impact on different classes of cytotoxic agents, on drug-drug int...

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Main Authors: Zhou, Jun, Oliveira, Paula, Li, Xueli, Chen, Zhengming, Bepler, Gerold
格式: Artigo
語言:Inglês
出版: SAGE-Hindawi Access to Research 2010
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2952906/
https://ncbi.nlm.nih.gov/pubmed/20976259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4061/2010/597098
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