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Effects of PCSK9 genetic variants on plasma LDL cholesterol levels and risk of premature myocardial infarction in the Italian population

The R46L variant in the proprotein-convertase subtilisin-kexin type 9 (PCSK9) gene was associated with reduced levels of LDL and total cholesterol and with a lower risk of coronary artery disease. We investigated the association of R46L with myocardial infarction (MI) in 1,880 Italian patients with...

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Detalhes bibliográficos
Main Authors: Guella, Ilaria, Asselta, Rosanna, Ardissino, Diego, Merlini, Pier Angelica, Peyvandi, Flora, Kathiresan, Sekar, Mannucci, Pier Mannuccio, Tubaro, Marco, Duga, Stefano
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2952575/
https://ncbi.nlm.nih.gov/pubmed/20699424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M010009
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