Macrophage ABCA1 reduces MyD88-dependent Toll-like receptor trafficking to lipid rafts by reduction of lipid raft cholesterol

We previously showed that macrophages from macrophage-specific ATP-binding cassette transporter A1 (ABCA1) knockout (Abca1(-M/-M)) mice had an enhanced proinflammatory response to the Toll-like receptor (TLR) 4 agonist, lipopolysaccharide (LPS), compared with wild-type (WT) mice. In the present stud...

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Autori principali: Zhu, Xuewei, Owen, John S., Wilson, Martha D., Li, Haitao, Griffiths, Gary L., Thomas, Michael J., Hiltbold, Elizabeth M., Fessler, Michael B., Parks, John S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Biochemistry and Molecular Biology 2010
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2952560/
https://ncbi.nlm.nih.gov/pubmed/20650929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M006486
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