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Synergistic Dual Automaticity in Sinoatrial Node Cell and Tissue Models

BACKGROUND: The mechanism of sinoatrial node (SAN) automaticity is traditionally attributed to membrane ion currents. Recent evidence indicates spontaneous sarcoplasmic reticulum (SR) Ca(2+) cycling also plays an important role. METHODS AND RESULTS: We performed computer simulation on SAN cell and 1...

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Main Authors: Zhang, Hong, Joung, Boyoung, Shinohara, Tetsuji, Xi, Mei, Chen, Peng-Sheng, Lin, Shien-Fong
格式: Artigo
語言:Inglês
出版: 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2952528/
https://ncbi.nlm.nih.gov/pubmed/20679733
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