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Transition state of ADP-ribosylation of acetyllysine catalyzed by Archeaglobus fulgidus Sir2 determined by kinetic isotope effects and computational approaches
Sirtuins are protein modifying enzymes distributed throughout all forms of life. These enzymes bind NAD(+), a universal metabolite, and react it with acetyllysine residues to effect deacetylation of protein side chains. This NAD(+)-dependent deacetylation reaction has been observed for sirtuin enzym...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2952425/ https://ncbi.nlm.nih.gov/pubmed/20718419 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja910342d |
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