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Chromogranin B regulates calcium signaling, NF-κB activity and BNP production in cardiomyocytes

Altered regulation of signaling pathways can lead to pathologies including cardiac hypertrophy and heart failure (HF). We report that neonatal and adult cardiomyocytes express chromogranin B (CGB), a calcium (Ca(2+)) binding protein which modulates Ca(2+) release by the inositol 1,4,5-trisphosphate...

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Autors principals: Heidrich, Felix M., Zhang, Kun, Estrada, Manuel, Huang, Yan, Giordano, Frank J., Ehrlich, Barbara E.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2952358/
https://ncbi.nlm.nih.gov/pubmed/18420944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.107.166033
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